In the vast universe of cosmetic ingredients, few can boast the versatility and effectiveness of Niacinamide. Also known as Vitamin B3 or nicotinamide, this powerful water-soluble vitamin has earned a place of honor in the skincare routines of millions of people worldwide. Its popularity is not a matter of chance, but the result of solid scientific research supporting its ability to address a wide range of skin concerns, from acne and excess oil to hyperpigmentation, redness, and signs of aging.
What is Niacinamide and How Does It Work?
Niacinamide is an active form of Vitamin B3, an essential nutrient that our body needs for various metabolic functions. In the field of skincare, it stands out for its ability to penetrate the epidermis and exert its effects at the cellular level. Unlike other ingredients that may be specific to a single problem, Niacinamide offers a holistic approach, improving the overall health of the skin.
Its mechanism of action is complex and multifactorial. It acts as a precursor to important coenzymes that are crucial for DNA repair reactions, cellular energy production, and modulation of inflammatory pathways. Research has shown that niacinamide protects glycolysis and cellular ATP levels, counteracting the decrease caused by oxidative stress in human dermal fibroblasts.
The Transformative Benefits of Niacinamide
1. Strengthens the Skin Barrier
One of the most significant benefits of Niacinamide is its ability to improve the skin's barrier function. It stimulates the synthesis of ceramides, fatty acids, and cholesterol, essential lipid components of the stratum corneum. A robust skin barrier is crucial to retain moisture, protect against transepidermal water loss, and defend the skin from environmental aggressors such as pollution and irritants.
It has been shown that in patients with atopic dermatitis, niacinamide significantly increases ceramide synthesis up to five times more, with a dose-dependent effect.
2. Regulates Sebum Production and Minimizes Pores
For combination and oily skin, Niacinamide is an invaluable ally. It helps regulate sebum production from the sebaceous glands, which can reduce excessive shine and the appearance of enlarged pores. A recent study published in Applied Sciences demonstrated that the use of a commercial cream with niacinamide for three weeks significantly improved skin hydration under real use conditions.
3. Fights Acne and Imperfections
Thanks to its anti-inflammatory and sebum-regulating properties, Niacinamide is effective in treating acne. In a study with 160 patients with moderate acne, 4% niacinamide gel showed a significantly greater improvement in reducing sebum compared to 1% clindamycin gel.
These results are especially relevant because the side effects of niacinamide are considerably safer than antibiotics and it does not generate resistant pathogens.
4. Reduces Hyperpigmentation and Evens Skin Tone
Niacinamide interferes with the transfer of melanosomes from melanocytes to keratinocytes. This mechanism helps reduce the appearance of dark spots, whether caused by the sun, age, inflammation, or melasma. With continued use, the skin acquires a more even and luminous tone.
5. Soothes the Skin and Reduces Redness
Its anti-inflammatory properties make Niacinamide beneficial for calming irritated skin and reducing redness associated with conditions such as rosacea, eczema, or general sensitivity.
6. Antioxidant Action
Niacinamide helps protect the skin from damage caused by free radicals generated by UV exposure and pollution. It contributes to the overall defense of the skin against oxidative stress, preventing premature aging.
7. Improves Elasticity and Reduces Signs of Aging
By improving barrier function, hydration, and stimulating collagen production, Niacinamide can help improve skin elasticity and soften the appearance of fine lines and wrinkles.
8. Improves the Skin Microbiome
*NEW 2025: Recent research has revealed a fascinating additional benefit of niacinamide: its ability to improve the skin microbiome. Niacinamide increases the production of antimicrobial peptides, which helps maintain a healthy balance in the skin flora.
9. Skin Cancer Prevention
*REVOLUTIONARY FINDING in 2025: One of the most significant discoveries of 2025 comes from a massive study published in JAMA Dermatology by researchers at Vanderbilt University. The study, which included 33,822 patients from the US veterans hospital network, demonstrated that oral nicotinamide supplementation is associated with a 14% reduction in the incidence of non-melanoma skin cancer.
The results are even more impressive in certain subgroups. In patients who started the supplement after their first skin cancer diagnosis, the risk of developing a new skin cancer dropped by up to 54%. The effect was particularly pronounced in cutaneous squamous cell carcinoma, with a 22% reduction.
Important note: As Dr. Gabriela Cinat, oncologist at the University of Buenos Aires, points out, niacinamide should be considered a complement, not a substitute, for classic skin cancer prevention measures. Daily use of broad-spectrum sunscreen, appropriate clothing, self-examinations, and regular dermatological check-ups remain the most effective strategies.
Niacinamide in the divain Care Line
divain Care, always at the forefront of cosmetic innovation, has recognized the multifaceted power of Niacinamide and incorporated it into key products designed to transform your skin.
A product that stands out for its potential is our CICA-LIFT Face Mask. Facial tonics formulated with Niacinamide are excellent for balancing the skin after cleansing, minimizing the appearance of pores, controlling excess oil, and preparing the skin for the next steps in the routine.
Niacinamide serums are highly effective due to their ability to deliver an optimal concentration of the active ingredient to the skin. A serum with these characteristics would be ideal for treating acne outbreaks, reducing inflammation, minimizing post-acne marks, and improving the overall texture of skin prone to imperfections.
Incorporating Niacinamide into Your Routine
In the morning and/or at night: After facial cleansing, apply with the palms of your hands over the face and neck. This will help balance the skin's pH, refine pores, and prepare it for better absorption of subsequent products.
Next: Apply a few drops of serum on clean, dry skin, focusing on problem areas if necessary, or on the entire face for a global benefit. Gently massage until fully absorbed.
Continue with your usual routine: After the serum, apply your moisturizer and, especially in the morning, a broad-spectrum sunscreen. Niacinamide is compatible with most cosmetic ingredients, including retinol, Vitamin C, hyaluronic acid, and AHA/BHA.
Niacinamide is, without a doubt, a star ingredient in skincare, capable of offering a comprehensive solution to a multitude of skin concerns. The most recent discoveries of 2024 and 2025 have further expanded our understanding of this versatile ingredient, revealing its ability to improve the skin microbiome and, in a revolutionary way, significantly reduce the risk of skin cancer.
By choosing products containing Niacinamide, such as those offered by our divain Care line, you are investing in the long-term health and balance of your skin. Its high tolerability makes it an excellent option for almost all skin types, including sensitive ones.
0 comments